Blood transfusions and transmissible viruses
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Abstract
The authors present the main viruses transmissible by blood transfusion such as human immunodeficiency viruses (HIV1-2) and hepatitis B and C viruses (HBV and HCV respectively).
The recent introduction of the leukodepletion methodology has made an important contribution in reducing the transmission rate of leukotropic viruses such as cytomegalovirus (CMV), Epstein-Barr Virus (EBV), human herpesvirus, human T-cell leukemia virus (HTLV 1-2 ).
Advances in molecular biology have made it possible to highlight that other viruses, considered less important pathogens such as hepatitis A and G viruses (HAV, HGV), human Parvovirus B19, Reovirus type 3 and Pseudorabbia virus can be transmitted to recipients. Furthermore, emerging viruses with potential zoonotic risk could play a non-marginal role in the spread of infection.
Much attention is now being paid to diseases due to emerging viruses such as hepatitis E (HEV), hantaviruses, West Nile Disease virus and Crimean-Congo hemorrhagic fever virus.
The authors followed the validation procedures in line with the European standards of the European Medicines Agency (EMA).
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