Covid19 and kidney disease
Article Sidebar
Main Article Content
Abstract
Angiotensin-converting enzyme 2 (ACE2) has been identified as a potential SARS- CoV receptor. The renin-angiotensin system has a crucial role in severe acute lung injury and cell injury The high lethality of SARS-CoV infections, its enormous economic and social impact, fears of renewed outbreaks as well as the potential misuse of such viruses
We show that prevalence of kidney disease on admission, and the development of acute kidney disease during hospitalization, is high and is associated with in-hospital mortality,
A similar pattern was seen for proteinuria, and for hematuria, although the risks were even higher for the latter.
For those with AKI, the risk of dying was almost doubled for stage 1 to more than quadrupled for stage 3.
Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney diseases, including acute kidney injury, and examine the potential effects of ARBs on the outcomes of patients with COVID-19. Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, particularly those in dialysis and with kidney transplants.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Viglione G. Tens of thousands of scientists are redeploying to fight coronavirus. Nature. 2020 Mar 27
Wang L, Li X, Chen H, Yan S, Li D, Li Y, Gong Z
Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China. Am J Nephrol. 2020 Mar 31:1-6..
Cheng Y, Luo , Wang K, Zhang M, Wang Z, Dong L, Li J, Yao Y, Ge S, Xu G. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020 Mar 20. pii: S0085-2538(20)30255-6.
Li Z, Wu M, Yao J, Guo J, Liao X, et al. (2020) Caution on Kidney Dysfunctions of COVID-19 Patients. medRxiv:2020.02.08.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet 395:1054-1062.
https://www.ilgiorno.it/bergamo/cronaca/virus-rene-1.5139433
Ronco C,, Reis T. Kidney involvement in COVID-19 and rationale for extracorporeal therapies.
Nat Rev Nephrol. 2020 Apr 9.
Hua Su, Ming Yang, Cheng Wan, Li-Xia Yi, Fang Tang, Hong-Yan Zhu, Fan Yi, Hai-Chun Yang, Agnes B. Fogo, Xiu Nie and Chun Zhang Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China Kidney Int. 2020 Apr 9.
Claudio Ronco , Thiago Reis,Silvia De Rosa , Coronavirus Epidemic and Extracorporeal Therapies in Intensive Care: si vis pacem para bellum Blood Purif March 2020
Damon M, Clec’h C., Adrie C, Argaud L., Allaouchiche B., Azoulay E., Bouadma L., Garrouste-Orgeas M., Haouache H., Schwebel C., Goldgran-Toledano D., Khallel H., Dumenil AS, Jamali S, Souweine B., Zen F.i, Cohen Y., Timsit JF Acute Respiratory Distress Syndrome and Risk of AKI among Critically Ill Patients Clin J Am Soc Nephrol. 2014 Aug 7; 9(8): 1347–1353.
Panitchote A, Mehkri O, Hastings A, Hanane T, Demirjian S, Torbic H, Mireles-Cabodevila E, Krishnan S, Duggal A. Factors associated with acute kidney injury in acute respiratory distress syndrome. Ann Intensive Care. 2019 Jul 1;9(1):74.
Hassan Izzedine 1 , Kenar D Jhaveri 2 , Mark A Perazella COVID-19 Therapeutic Options for Patients With Kidney Disease Kidney Int . 2020 Mar 30;S0085-2538(20)30349-5.
Honore PM, Hoste E, Molnár Z, Jacobs R, Joannes-Boyau O, Malbrain MLNG, Forni LG. Cytokine removal in human septic shock: Where are we and where are we going? Ann Intensive Care. 2019 May
Turani F, Barchetta R, Falco M, Busatti S, Weltert L. Continuous Renal Replacement Therapy with the Adsorbing Filter oXiris in Septic Patients: A Case Series. Blood Purif. 2019;47 Suppl 3:1-5.
Ronco C, Reis T, De Rosa S Coronavirus Epidemic and Extracorporeal Therapies in Intensive Care: si vis pacem para bellum Blood Purif. 2020 Mar 13:1-4.
Stahl K, Schmidt BMW, Hoeper MM3, Skripuletz T, Möhn N, Beutel G, Eder M, Welte T, Ganser 9, Falk CS, Koenecke C, David S Extracorporeal cytokine removal in severe CAR-T cell associated cytokine release syndrome.
J Crit Care. 2020 Feb 19;57:124-129
Bottari G, Merli P, Guzzo I, Stoppa F, Ruggeri A, Di Nardo M, Del Bufalo F, Galaverna F, Corrado C, Locatelli F.
Multimodal Therapeutic Approach of Cytokine Release Syndrome Developing in a Child Given Chimeric Antigen Receptor-Modified T Cell Infusion. Crit Care Explor. 2020 Jan 29;2(1)
Yimin Zhang a, Liang Yu a, LingLing Tang b, Mengfei Zhu b, Yanqi Jin a, Zhouhan Wang a, Lanjuan Li a, A Promising Anti-Cytokine-Storm Targeted Therapy for COVID-19: The Artificial-Liver Blood-Purification System
Engineering (Beijing). 2020 Mar 20
https://sinitaly.org/coronavirus/
Guan WJ, Ni ZY, Hu Y, Liang Whet al China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-1720.
Effect of continuous renal replacement therapy on all-cause mortality in COVID-19 patients undergoing invasive mechanical ventilation: a retrospective cohort study Yi Yang*, Jia Shi*, Shuwang Ge*, Shuiming Guo, Xue Xing, Yanan Wang, Anying Cheng, Qingquan Liu, Junhua Li, Yong Ning, Fan He#, Gang Xu
MedRxiv March 20, 2020
See EJ, Jayasinghe K, Glassford N, Bailey M, Johnson DW, Polkinghorne KR, Toussaint ND, Bellomo R Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure. Kidney Int. 2019 Jan;95(1):160-172.
Luca Perico 1 , Ariela Benigni 1 , Giuseppe Remuzzi Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade 3. 2020 Mar 23;1-9.
Muthiah Vaduganathan, M.D., M.P.H., Orly Vardeny, Pharm.D., Thomas Michel, M.D., Ph.D., John J.V. McMurray, M.D., Marc A. Pfeffer, M.D., Ph.D., and Scott D. Solomon,Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19 N Engl J Med 2020; 382:1653-1659
Verdecchia P, Reboldi G, Cavallini C, Mazzotta G, Angeli F. ACE-inhibitors, angiotensin receptor blockers and severe acute respiratory syndrome caused by coronavirus. G Ital Cardiol (Rome). 2020 May;21(5):321-327
Peng Zhang , LiHua Zhu , Jingjing Cai et al: Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19 Circulation Research. Originally published17 Apr 2020
https://sinitaly.org/wp-content/uploads/2020/05/2-Survey-Covid-19-SIN-1.pdf
Carlo Basile, Christian Combe, Francesco Pizzarelli, Adrian Covic, Andrew Davenport, Mehmet Kanbay, Dimitrios Kirmizis, Daniel Schneditz, Frank van der Sande, Sandip Mitra on behalf of the EUDIAL Working Group of ERA-EDTARecommendations for the prevention, mitigation and containment of the emerging SARS-CoV-2 (COVID-19) pandemic in haemodialysis centres. Nephrology Dialysis Transplantation, Volume 35, Issue 5, May 2020,
Giuseppe Rombolà , Marco Heidempergher , Luciano Pedrini , Marco Farina , Filippo Aucella , Piergiorgio Messa , Giuliano Brunori Practical Indications for the Prevention and Management of SARS-CoV-2 in Ambulatory Dialysis Patients: Lessons From the First Phase of the Epidemics in Lombardy 2020
J Nephrol . 2020 Apr;33(2):193-196.
P. Toby Coates, Germaine Wong, Tilman Drueke, Brad Rovin, Pierre Ronco, Early experience with COVID19 in kidney transplantation Kidney International (2020) -,Apr 9 2020
Alberici F, Delbarba E, Scolari F. et al A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia Kidney Int, April, 9, 2020
Banerjee D, Popoola J, Shah S, Ster IC, Quan V, Phanish M. COVID-19 infection in kidney transplant recipients.
Kidney Int. 2020 Apr 9 2020