Celiac disease and multiple sclerosis a possible relationship
Article Sidebar
Main Article Content
Abstract
Celiac disease (CD) is an autoimmune disease characterized by a permanent intolerance to gluten.
It involves genetically predisposed individuals causing inflammation of the duodenum until the atrophy of the villi. Gluten is the protein complex content in grains such as wheat, barley, rye, spelled, kamut, triticale and spelled wheat.
The CD has a prevalence of 1:100(1). It is more frequent among women with a male/female ratio of 1:2.
The risk of CD is higher in type 1 diabetes mellitus (DM type 1), in Down syndrome, in IgA deficiency and in relatives of first degree of celiac patients.
The gluten crosses the barrier duodenal through the opening of tight junctions, inside the duodenum it is deamidated by tissue transglutaminase.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Coeliac disease. A. Di Sabatino, G.R. Corazza. Lancet 2009; 373: 1480-93.
Grains of truth: evolutionary changes in small intestinal mucosa in response to environmental antigen challenge. Marsh MN. Gut. 1990 Jan; 31 (1): 111-4. Review.
Neuropathy associated with gluten sensitivity. M Hadjivassiliou et al. J Neurol Neurosurg Psychiatry 2006;77:1262-1266.
Brain White-Matter Lesions in Celiac Disease: A Prospective Study of 75 Diet-Treated Patients. Matthias Kieslich et al. Pediatrics 2001;108;e21
Leaky Gut and Autoimmune Diseases. Alessio Fasano. Clinic Rev Allerg Immunol (2012) 42:71-78