leukemic non-nodal mantle cell lymphoma a case report with a feasibility study of the application of cytomatrix to bone marrow examination
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Abstract
Leukemic non-nodal mantle cell lymphoma is a mantle lymphoma in which the patient presents with peripheral blood, bone marrow and splenic involvement without significant adenopathy.
Neoplastic cells may resemble other small B-cell lymphoid neoplasms, but show CCND1 translocation.
CytoMatrix is a synthetic matrix which has the ability to capture and preserve, within its threedimensional structure, the biological material obtained from fine-needle aspiration.
We report a case of leukemic non-nodal mantle cell lymphoma with an exhaustive immunohistochemical and molecular characterization obtained through trephine biopsy and bone marrow aspiration prepared with CytoMatrix technique.
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References
Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. eds. World Health Organization Classification of Tumours, Revised 4th Edition. Lyon, France: IARC; 2017.
Bruschini, S., et al., CytoMatrix for a reliable and simple characterization of lung cancer stem cells from malignant pleural effusions. J Cell Physiol, 2019.
Tiacci, E., et al., BRAF mutations in hairy-cell leukemia. N Engl J Med, 2011. 364(24): p. 2305-15.
Vose, J.M., Mantle cell lymphoma: 2015 update on diagnosis, risk-stratification, and clinical management. Am J Hematol, 2015. 90(8): p. 739-45.
Golardi, N., M.R. Velasco, and M.T. Elghetany, Marginal zone variant of mantle cell lymphoma: CD5-negative cyclin D1- positive variant posing a diagnostic dilemma. Pathol Int, 2009. 59(5): p. 317-21.
Hashimoto, Y., et al., CD5-negative mantle cell lymphoma resembling extranodal marginal zone lymphoma of mucosaassociated
lymphoid tissue : a case report. J Clin Exp Hematop, 2012. 52(3): p. 185-91.
Mansoor, A., et al., Cyclin D1 and t(11;14)-positive B-cell neoplasms resembling marginal zone B-cell lymphoma: a morphological variant of mantle cell lymphoma. Hum Pathol, 2007.38(5): p. 797-802.
Seok, Y., et al., CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations. Ann Lab Med, 2012. 32(1): p. 95-8.
Ribera-Cortada, I., et al., Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype. Mod Pathol, 2015. 28(11): p. 1435-47.
Miao, Y., et al., CD5-negative Mantle Cell Lymphoma: Clinicopathologic Correlations and Outcome in 58 Patients. Am J Surg Pathol, 2019. 43(8): p. 1052-1060.
Sander, B., et al., Mantle cell lymphoma--a spectrum from indolent to aggressive disease. Virchows Arch, 2016. 468(3): p. 245-57.
Ondrejka, S.L., et al., Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis,interstitial bone marrow involvement, kappa light chain restriction, and good prognosis. Haematologica, 2011. 96(8): p. 1121-7.
Xu, J., et al., SOX11-negative Mantle Cell Lymphoma:Clinicopathologic and Prognostic Features of 75 Patients. Am J Surg Pathol, 2019. 43(5): p. 710-716.
Balsas, P., et al., SOX11 promotes tumor protective microenvironment interactions through CXCR4 and FAK regulation in mantle cell lymphoma. Blood, 2017. 130(4): p. 501-513.