Il Ruolo chiave dell'annessina A2 e della plasmina nella fisiopatologia del COVID -19 presentazione clinica e risultati
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Abstract
La pandemia della malattia da Coronavirus 2019 (COVID-19) è diventata una crisi sanitaria globale determinante con un tasso di trasmissione eccezionalmente alto che causa morbilità e mortalità significative.
Studi recenti hanno riportato pazienti che presentavano disturbi della coagulazione e malattia tromboembolica successivamente risultati positivi al coronavirus.
In questo articolo, abbiamo discusso la recente tendenza nella sintomatologia di covid19 inclusa la trombosi microvascolare e il potenziale ruolo chiave di proteine come annessina A2, plasmina, recettori ACE-2 e canali ENaC nella fisiopatologia della malattia.
Le interazioni tra queste molecole e le proteine virali potrebbero svolgere un ruolo nella presentazioe tromboembolica della malattia e spiegare la morbilità selettiva nei pazienti con condizioni ci comorbidità.
È stato anche proposto un modello di lavoro schematico che aiuterà i lettori a comprendere queste interazioni biomolecolari chiave che influenzano la probabile fisiopatologia a livello di recettore cellulare.
Questo articolo farà anche luce sui polimorfismi genetici nei recettori ACE-2 e annessina A2, suggerendo una possibilità di ampia diversità nella presentazione clinica e gravità della malattia in tutto il mondo.
Studi basati sull'evidenza potrebbero guidare nell'identificazione di potenziali terapie e opzioni di trattamento per COVID-19
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Questo lavoro è fornito con la licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 4.0 Internazionale.
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