Rheumatoid arthritis in internal medicine from pathogenesis to personalized medicine
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Abstract
Rheumatoid arthritis is a chronic multisystem disease, characterized by persistent synovitis, in general affecting the peripheral joints, affected symmetrically. Symptoms can be articular and extra-articular (joint swelling, pain, typical morning stiffness upon awakening, asthenia, generalized malaise, sometimes low-grade fever, weight loss, joint deformity).
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